Table 1. Association of the sixteen loci reaching genome-wide significance in combined analyses.
| Stage one (UKB)† | Stage two cohorts | Combined | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rsID | Gene* | All. | EAF | Effect‡ | S.E. | P-value | Effect‡ | S.E. | P-value | Effect‡ | S.E. | P-value | N |
| rs958685 | TGFA | A/C | 0.52 | 0.154 | 0.026 | 2.8 × 10−9 | 0.164 | 0.04 | 3.8 × 10−5 | 0.157 | 0.022 | 4.8 × 10−13 | 191,754 |
| rs72979233 | POLD3 | A/G | 0.76 | 0.210 | 0.03 | 3.7 × 10−12 | 0.112 | 0.041 | 5.8 × 10−3 | 0.175 | 0.024 | 5.0 × 10−13 | 192,490 |
| rs11614333 | ERP27 | C/T | 0.62 | 0.181 | 0.027 | 5.0 × 10−11 | 0.117 | 0.04 | 3.5 × 10−3 | 0.16 | 0.023 | 1.6 × 10−12 | 195,154 |
| rs2288278 | HOXB3 | A/G | 0.66 | 0.162 | 0.027 | 3.0 × 10−9 | 0.147 | 0.04 | 2.8 × 10−4 | 0.157 | 0.023 | 3.8 × 10−12 | 195,133 |
| rs4926611 | GLIS1 | C/T | 0.64 | 0.173 | 0.027 | 1.3 × 10−10 | 0.115 | 0.041 | 5.1 × 10−3 | 0.156 | 0.023 | 4.8 × 10−12 | 192,964 |
| rs6687430 | PEX14 | G/A | 0.46 | 0.15 | 0.026 | 7.6 × 10−9 | 0.124 | 0.04 | 1.7 × 10−3 | 0.142 | 0.022 | 5.6 × 10−11 | 195,176 |
| rs10186876 | LRPPRC | A/G | 0.36 | 0.162 | 0.027 | 2.7 × 10−9 | 0.113 | 0.041 | 6.2 × 10−3 | 0.147 | 0.023 | 9.8 × 10−11 | 192,490 |
| rs374532236 | MGMT | T/C | 0.38 | 0.157 | 0.027 | 5.5 × 10−9 | 0.121 | 0.042 | 4.2 × 10−3 | 0.147 | 0.023 | 1.1 × 10−10 | 189,701 |
| rs10861798 | SYT1 | A/G | 0.43 | 0.145 | 0.026 | 4.3 × 10−8 | 0.159 | 0.047 | 7.4 × 10−4 | 0.148 | 0.023 | 1.3 × 10−10 | 189,160 |
| rs78325334 | HLA | T/C | 0.84 | 0.228 | 0.038 | 2.4 × 10−9 | 0.113 | 0.05 | 0.024 | 0.186 | 0.03 | 9.6 × 10−10 | 193,127 |
| rs2273555 | GBF1 | A/G | 0.61 | 0.153 | 0.027 | 9.1 × 10−9 | 0.096 | 0.041 | 0.019 | 0.136 | 0.022 | 1.1 × 10−9 | 191,754 |
| rs80103986 | KANSL1 | A/T | 0.81 | 0.201 | 0.033 | 1.8 × 10−9 | 0.098 | 0.052 | 0.059 | 0.171 | 0.028 | 1.2 × 10−9 | 193,090 |
| rs2110927 | SLC8A1 | C/T | 0.27 | 0.161 | 0.029 | 4.4 × 10−8 | 0.098 | 0.045 | 0.029 | 0.142 | 0.025 | 7.7 × 10−9 | 192,490 |
| rs6565586 | ACTG1 | A/T | 0.25 | 0.169 | 0.03 | 2.2 × 10−8 | 0.096 | 0.064 | 0.14 | 0.156 | 0.027 | 1.2 × 10−8 | 187,072 |
| rs72762373 | DEC1 | A/G | 0.03 | 0.424 | 0.078 | 4.9 × 10−8 | 0.359 | 0.255 | 0.16 | 0.418 | 0.074 | 1.8 × 10−8 | 152,162 |
| rs34845616 | IGSF9B | A/G | 0.25 | 0.168 | 0.03 | 1.7 × 10−8 | 0.07 | 0.049 | 0.15 | 0.141 | 0.025 | 2.7 × 10−8 | 189,666 |
All, alleles (effect/other); EAF, effect allele frequency; HLA, HLA region; N, sample size; UKB, UK Biobank.
Results are sorted by combined stage one+stage two P-value.
*Nearest gene to the lead SNP.
†Stage one analyses include 142,035 participants.
‡Effect estimates are in kg per allele and correspond to the first allele shown.