Table 1.
Basic Information for Included Studies of CRS Animal Model Development.
| First Author, Publication Year | Country | Animal | Materials | Need Surgery | Develop Period | Diseases | Established Model |
|---|---|---|---|---|---|---|---|
| Khalmuratova, 20166 | South Korea | Mouse (B6) | HDM and SEB | No | 103 days | CRS with NP | Develop modified polyp model using aeroallergen (HDM) |
| Kim, 201444 | South Korea | Mouse (BALB/c) | Aspergillus protease and OVA | No | 5 weeks | CRS | Develop modified eosinophilic CRS model with Aspergillus protease |
| Migliavacca, 201415 | Brazil | Rabbit (New Zealand) | – | Yes | 12 weeks | CRS | Develop the animal model of CRS in rabbits without bacterial innoculation |
| Jia, 201411 | China | Rabbit (New Zealand) | S. aureus | Yes | 2–8 weeks | Sinusitis (biofilms) | Develop the animal model of Staphylococcus aureus biofilm in CRS |
| Kim, 20115 | South Korea | Mouse (BALB/c) | OVA and SEB | No | 103 days | CRS with NP | Develop a murine polyp model |
| Boase, 201112 | Australia | Sheep | Aspergillus fumigatus/Alternaria alternata/S. aureus | Yes | 38 days | CRS | Develop modified CRS sheep model for fungal biofilms in sinusitis |
| Tansavatdi, 201013 | United States | Mouse (BALB/c) | Aspergillus fumigatus | No | 12 weeks | CRS | Develop an animal model for wound healing in CRS |
| Liang, 200814 | Taiwan | Rabbit (New Zealand) | PMA and Merocel Medtronic | Yes | 12 weeks | CRS | Develop an animal model for rhinogenic CRS |
| Ha, 20074 | Australia | Sheep | S. aureus | Yes | 7 days | Sinusitis (biofilms) | Demonstrate bacterial biofilms in an animal model of sinusitis |
| Lindsay, 20067 | United States | Mouse (BALB/c) | Aspergillus fumigatus | No | 12 weeks | CRS | Develop an animal model for CRS |
CRS = chronic rhinosinusitis; HDM = house dust mite; NP = nasal polyp; OVA = ovalbumin; PMA = phorbol 12‐myristate 13‐acetate; SEB = Staphylococcus aureus enterotoxin B.