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. 2017 Jan 17;2(1):10–18. doi: 10.1002/lio2.37

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© 2017 The Authors Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Site of first progression in HPV‐positive and HPV‐negative oropharyngeal squamous cell carcinoma. Published studies35, 98, 99 describing the first event of recurrence were evaluated to determine the proportion of first recurrence events in OPC representing locoregional recurrence or distant metastatic disease. Patients who experienced local or regional recurrence without distant metastases were categorized as locoregional recurrence (LR). Patients who experienced distant metastasis as the first event of recurrence, with or without concurrent local or regional recurrence, were categorized as distant metastasis (DM). Data was pooled across studies and proportion with LR and DM as first event were calculated and compared by HPV tumor status using chi‐square test (GraphPad Prism 7, La Jolla, CA). Pie charts represent the proportional contribution of locoregional recurrence (LR) and distant metastasis (DM) as the site of first progression in HPV‐positive and HPV‐negative oropharyngeal squamous cell carcinoma (OPC). Based on pooled data from Nguyen‐Tan et al, Guo et al, and Sinha et al35, 98, 99. Patients with synchronous DM and LR were included in the DM subgroup.