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. 2017 Jul 14;8:335. doi: 10.3389/fneur.2017.00335

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Copyright © 2017 Namer, Ørstavik, Schmidt, Mair, Kleggetveit, Zeidler, Martha, Jorum, Schmelz, Kalpachidou, Kress and Langeslag.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Voltage-gated sodium current recordings in mature Gla^−/0 and Wildtype (Wt) nociceptors. (A) Typical examples of voltage-gated Na⁺ currents from Wt and Gla^−/0 cultured sensory neurons recorded under normal condition (left panel, I_{Na Total}) and after application of 250 nm TTX (right panel, I_{Na TTX}) at depolarizing test pulses from −55 to 15 mV at 10 mV steps. (B) IV-curves of voltage-gated Na⁺ currents measured in Wt (white symbols) and Gla^−/0 (black symbols) nociceptors under control (left panel) and TTX (right panel) conditions. The IV-curves were derived from the recordings shown in (A). (C) The Na⁺ conductance of Gla^−/0 nociceptors was significantly reduced (*p < 0.05, MWU) whereas the (D) activation voltage (V_{Na_act}) was unchanged.