. 2017 Jun 5;6(5):R80–R86. doi: 10.1530/EC-17-0081
This work is licensed under a Table 2.
Summary of previous published cases of small-cell (neuroendocrine) prostate cancer.
| Author | Year | Patient age | Stage | Prior hx adenoCa | MR blockade | CS treatment | Chemotherapy | Survival from CS dx | Cause of death |
|---|---|---|---|---|---|---|---|---|---|
| Webster (7) | 1959 | 68 | Metastatic | 2 months prior | No | No | No | <1 week | Sepsis |
| Wise (23) | 1965 | 58 | Metastatic | 38 months prior | No | Bilateral adrenalectomy | No | Approx. 2 months | Not stated |
| Hall (37) | 1968 | 63 | Metastatic | 36 months prior | No | No | No | 2 months | Coma, hypotension |
| Newmark (26) | 1973 | 57 | Metastatic | 48 months prior | Yes | Mitotane, metyrapone | No | 8 days | Sepsis |
| Lovern (24) | 1975 | 66 | Metastatic | 48 months prior | No | Bilateral adrenalectomy | No | 3 months | Liver failure secondary metastatic disease |
| Wenk (27) | 1977 | 62 | Locally advanced | 8 months prior | No | No | No | 23 days | Sepsis |
| Molland (38) | 1978 | 76 | Locally advanced | No | Not stated | Not stated | No | 4 weeks | Coma? cause |
| Statham (39) | 1981 | 63 | Metastatic | 36 months prior | No | Metyrapone | No | 2 months | Renal failure |
| Vuitch (28) | 1981 | 70 | Metastatic | 23 months prior | Not stated | Not stated | Not stated | 2 months | Aspergillus |
| Carey (35) | 1984 | 66 | Metastatic | No | Not stated | Not stated | Doxorubicin, cyclophosphamide* | 22 days | Bronchopneumonia |
| Ghali (29) | 1984 | 76 | Metastatic | No | No | Mitotane | No | 6 weeks | Bronchopneumonia |
| Slater (30) | 1985 | 69 | Locally advanced | No | No | No | No | 1 week | Sepsis |
| Fjellestad-Paulsen (36) | 1988 | 63 | Metastatic | No | No | Ketoconazole | No | 6 days | Not stated |
| Haukaas (40) | 1999 | 74 | Metastatic | 4 months prior | Yes | Metyrapone | No | 80 days | Sepsis |
| Rickman (41) | 2001 | 69 | Metastatic | 24 months prior | Yes | Ketoconazole | No | 1 month | Not known |
| Hussein (31) | 2002 | 53 | Metastatic | 9 months prior | Yes | Ketoconazole | No | 2.5 months | Not stated |
| Nimalasena (42) | 2008 | 64 | Locally advanced | 26 months prior | No | Ketoconazole, metyrapone | No | 3.5 months | Not stated |
| Nimalasena (42) | 2008 | 52 | Metastatic | 10 months prior | No | Ketoconazole, metyrapone, octreotide | Epirubicine, carboplatin, 5FU | 1 month | Not stated |
| Alwani (25) | 2009 | 62 | Metastatic | No | No | Mifepristone, bilateral adrenalectomy | No | 3 weeks | Sepsis |
| Alshaikh (32) | 2010 | 70 | Locally advanced | No | No | Ketoconazole, metyrapone | Cisplatin, etoposide | 6 months | Sepsis |
| Rueda-Camino (17) | 2016 | 63 | Metastatic | No | No | Ketoconazole | Cisplatin, etoposide | 12 months | Brain metastases |
| Shrosbree (33) | 2016 | 71 | Metastatic | Not stated | No | Metyrapone | Carboplatin, etoposide | Not stated | Not stated |
| Ramalingam (34) | 2016 | 51 | Metastatic | 2 months prior | Yes | Ketoconazole | Cisplatin, etoposide | 12 months | Not stated |
| Balestrieri (15) | 2016 | 75 | Locally advanced | No | Yes | Ketoconazole, metyrapone, octreotide | No | 3 months | Intestinal perforation |
| Current case | 71 | Metastatic | No | Yes | Ketoconazole, metyrapone, octreotide | Carboplatin, etoposide | 9 months | Metastatic disease |
*
Died shortly after first dose.
AdenoCa, prostate adenocarcinoma; CS, Cushing’s syndrome; dx, diagnosis; hx, history; MR, mineralocorticoid.