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. Author manuscript; available in PMC: 2017 Dec 12.
Published in final edited form as: Nat Genet. 2017 Jun 12;49(7):1126–1132. doi: 10.1038/ng.3892

Figure 3. eQTL and smoking behavior analysis of the 8p21 lung cancer susceptibility locus. Upper panel.

Figure 3

Scatter plots of variants across the 8p21 locus and their associated with lung cancer (Y-axis) and CHRNA2 eQTL (X-axis) in lung epithelial tissues (panel a) and CHRNA2 eQTL in brain cerebellum tissues (panel b). Panel C. eQTL association between rs11780471 across tissues from different parts of the brain from GTEx and Braineac consortia noting CHRNA2 cis- eQTL effect appears restricted to the brain cerebellum. Panel D. Association between rs11780471 and smoking phenotypes, noting evidence for association between smoking status (ever vs never) and age of initiation, with lung cancer risk allele carriers (G) more likely to be ever smokers and take up smoking earlier. Fagerström Test for Nicotine Dependence (FTND) index, error bars indicate the 95% confidence intervals.