Table 1.
Epitope location, pathogenicity and antibody form of anti-Dsg1 monoclonal antibody.
| Name of antibodya | Epitope location of Dsg1 | Antibody form | |
|---|---|---|---|
| Pathogenic antibody | PF1-8-15 (3-30/3h) | Conformational epitope of AA89-101 of EC1 (Putative trans-adhesive interface) |
IgG and scFv |
| Non-pathogenic antibody | PF1-2-6 (1-18/L12) | Linear epitope of EC3 | IgG and scFv |
| PF1-2-22 (1-08/O12O2) | AA 1-161 of Dsg1 | IgG |
Abbreviations: Dsg1, desmoglein 1; PF, pemphigus foliaceus; EC, extracellular domain; AA, amino acid; scFv, single chain variable fragment.
a
Antibody name in parenthesis is based on gene usage of heavy and light chain [15].