Figure 1.

Dose-response curves of drug-induced vasodilation. Isolated aortic rings of MRP1^–/– LDLr^–/– double knockout mice (grey traces) and LDLr^–/– single knockout controls (black traces) were exposed to increasing concentrations of carbachol to measure endothelium-dependent vasorelaxation. Endothelial function was significantly improved in MRP1^–/– LDLr^–/– double knockout mice (A). Endothelium-independent vasorelaxation, which was measured upon administration of nitroglycerine, was similar in both groups (B). Absolute vascular tension was divided by maximum vascular tension to obtain relative vascular tension

Data are presented as mean ± standard error of the mean; n = 5–6; *p < 0.05. LDLr – low-density lipoprotein receptor, M – molar, MRP1 – multidrug resistance-associated protein 1.