Figure 3.

Assessment of atherosclerotic plaque burden. The atherosclerotic plaque burden was assessed in frozen sections through the aortic sinus and by subsequent oil red O staining (A, B). Total plaque volume was divided by the area of the vessel wall to produce relative plaque burden. MRP1-deficient mice exhibited a significantly reduced plaque burden compared to controls (C)

Data are presented as mean ± standard error of the mean; n = 6; *p < 0.05. Scale bar, 200 μm. LDLr – lowdensity lipoprotein receptor, MRP1 – multidrug resistanceassociated protein 1.