Corresponding histologic whole section for patient in Figure 4, with score of 3. (1) Extensive fibroelastotic scar tissue after neoadjuvant chemotherapy (partial response), with normal, partially emphysematic lung seen at bottom left. (2) Central portion of tumor, consisting of large calcifications, heavy elastosis, complete vessel remodeling, and enclosed anthracotic pigment. (3) Small residual focus of vital adenocarcinoma growing in lepidic fashion along alveolar walls. (Hematoxylin and eosin, ×10.)