Table 2.
Renin-angiotensin system components in lens, tears and lacrimal gland, vitreous, optic nerve head and sclera of the human eye.
RAS component | Lens | Tears/Lacrimal gland | Vitreous | Optic nerve head | Sclera | References |
---|---|---|---|---|---|---|
Prorenin | x | x | [24, 105, 107] | |||
Renin | x | x | [24, 105] | |||
AGT | x | x | [105, 110] | |||
ACE1 | x | x | x | x | [105, 112, 114, 115, 124-127] | |
ACE2 | ||||||
Ang I | x | [117] | ||||
Ang II | x | x | [111, 119] | |||
Ang(1–7) | ||||||
(P)RR | x | [105] | ||||
AT, unknown subtype | ||||||
AT1R | x | [119] | ||||
AT2R | x | [119] | ||||
AT4R | ||||||
MasR |
Table modified and updated from the table published by Holappa et al. [123]. ACE1, -2: Angiotensin converting enzyme 1, -2; AGT: Angiotensinogen; Ang I, -II: Angiotensin I, -II; Ang(1–7): Angiotensin (1–7); AT1R, -2R, -4R: Angiotensin II type 1, 2, 4 receptor; MasR: Mas receptor; (P)RR: (pro)renin receptor; RAS: Renin-angiotensin system.