Table I.
Association of TLM parameters with human embryo development in 15 eligible studies retrieved from electronic database search and reference list review
| Authors | Embryos no./ Patients no. | Start of imaging/ the time between image acquisition | Comments |
|---|---|---|---|
| Cetinkaya et al (2015) (43) |
3,354 /626 | time of insemination/ 20 min | Cleavage relative timings were better indicators of blastocyst formation and quality compared to absolute time-points |
| Storr et al (2015) (30) |
380/108 | time of ICSI/ 7 to 20 min | Eight significant predictive parameters of a top quality blastocyst were known: s3, t6, t7, t8, tM, tSB, tB and tEB * |
| Siristatidis et al (2015) (44) |
Not reported/239 | Time of ICSI/ 10 min | Early embryo morphokinetics parameters were associated with the subfertile patients characteristics |
| Almagor et al (2015) (45) |
Not reported/253 | Time of ICSI/ Not reported | Irregular cleavage embryos that are prevalent in younger women may have implantation potential and live birth. |
| Motato et al
(2015) (7) |
7,483/not reported | Time of ICSI/ 15 min | Morphokinetics parameters including tM t8-t5 interval, tEB could predict blastocyst formation and implantation ** |
| Sunddvall et al (2015) (46) |
1388/249 | Time of entry/ 20 min | Developmental timings in PCOS were not linked to live birth *** |
| Wdowiak et al (2015) (47) |
Not reported/165 | Time of ICSI/ 10 min | Higher SDF levels could be slow down morphokinetic parameters, and might be decreasing of pregnancy rate **** |
| Wu et al (2016) (48) |
212/109 | After PNA/ Not reported | The use of morphokinetic parameters to select embryo improved implantation and live birth rates |
| Adamson et al (2016) (49) |
Not reported/319 | After PNA/ Not reported | The use of combined conventional morphology and morphokinetics survey improved implantation rate |
| Mizobe et al (2016) (50). |
791/164 | Time of entry/ Not reported | Blastocyst transfers that derived from faster first and second cleavage embryos, improved pregnancy rate |
| Goodman et al (2016) (51) |
Not reported/235 | Time of entry/ 10 min | The use of morphokinetics was not improving ART outcomes, significantly. Although, it associated with blastocyst implantation rates |
| Liu et al
(2016) (29) |
Not reported/265 | Time of insemination/ 10 min | Qualitative and quantitative de-selection proposed model predicted implantation |
| Nogales et al
(2017) (52) |
485/112 | Time of ICSI/ 15 min | Chromosome aneuploidy affects embryo morphokinetics. TLM was useful to know discarded embryos |
*
S3: third synchronization, t6: time to 6 cells, t7: time to 7 cells, t8: time to 8 cells, tM: time of morula formation, tSB: time to sign of blastulation, tB: time to blastocyst, tEB: time to expanded blastocyst
**:
tM: time of morula formation, t8-t5: interval 5 cells to 8 cells, tEB: time to expanded blastocyst
***
: PCOS: poly cystic ovarian syndrome
****
: SDF: Sperm DNA fragmentation