Table 2. Putative functional consequences of SNP variants within the introgressed subregion (chr10: 48305073–48700082) of admixed highland dogs that contains PRKCE and EPAS1.
| CFA10 position | Allele | Gene | Consequence | Impact | Predicted SIFT phenotype (score) | Individuals carrying the allele |
|---|---|---|---|---|---|---|
| 48,284,953 | T | PRKCE | Missense | Moderate | Deleterious (0) | One highland wolf (qh4) |
| 48,631,974 | C | EPAS1 | Missense | Moderate | Deleterious (0.02) | Tibetan mastiff (DQZA81), low elevation indigenous dog (dc5) |