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. Author manuscript; available in PMC: 2018 Jan 18.
Published in final edited form as: Bioconjug Chem. 2016 Dec 12;28(1):194–202. doi: 10.1021/acs.bioconjchem.6b00545

Figure 4.

Figure 4

Inhibition of MGMT activity by BGS, DABGS, and IOPH-pBGS. Suppression of MGMT activity in SF767 cells treated with BG, BGS or DABGS at 10 and 20 μM Cells were harvested 2 h and 24 h after inhibitor addition. MGMT activity was determined from protein extractions by quantitating transfer of radioactivity from O6-[3H]methylguanine to MGMT. Data represent the results of a single preparation of IOPH-pBGS and are representative of results obtained from independent preparation of IOPH-pBGS.