Table 2.
Comparison of baseline predictors of response with patients that achieved a complete virological response or a virological response.
| Complete Virological Response^ | Virological Response° | |||||
|---|---|---|---|---|---|---|
| Yes | No | p-value | Yes | No | p-value | |
| N | 3 | 8 | 5 | 6 | ||
| Age (years)* | 49±4 | 41±14 | 0.311 | 45±15 | 42±12 | 0.271 |
| ALT (U/L)* | 98±93 | 181±155 | 0.311 | 84±70 | 221±161 | 0.071 |
| Alkaline Phosphatase (U/L)* | 62±10 | 123±60 | 0.0661 | 78±29 | 129±68 | 0.21 |
| Bilirubin (mg/dL)* | 0.6±0.2 | 1±0.4 | 0.0641 | 0.6±0.2 | 1.1±0.3 | 0.0061 |
| HBV-DNA >1000 IU/mL (%) | 1 (33%) | 1 (13%) | 0.492 | 1 (20%) | 1 (17%) | 1.02 |
| HBsAg (log10 IU/mL)* | 3.4±0.6 | 3.8±0.6 | 0.311 | 3.2±0.6 | 4.0±0.3 | 0.051 |
| HDV RNA (log10 GE/mL)* | 6.2±1.2 | 6.9±1.2 | 0.411 | 6.1±1.3 | 7.3±0.9 | 0.201 |
| HAI Inflammation (median) | 12 (7–14) | 10 (7–14) | 0.921 | 12 (7–14) | 10 (7–14) | 0.781 |
| Fibrosis (median, range) | 3 (3–3) | 4 (3–6) | 0.091 | 3 (3–4) | 4 (3–6) | 0.111 |
| Platelets (1000/uL)* | 153±71 | 138±54 | 0.841 | 142±56 | 143±60 | 1.01 |
| HVPG (mmHg)* | 8±0 | 11±7 | 0.791 | 12±89 | 9±4 | 0.521 |
| rs12979860 genotype (n=10) | 1.02 | 1.02 | ||||
| CC | 1 (50%) | 4 (50%) | 2 (50%) | 3 (50%) | ||
| CT | 1 (50%) | 4 (50% | 2 (50%) | 3 (50%) | ||
Mann-Whitney test
Fisher’s exact test
Mean (range)
Complete Virological Response = Undetectable HDV RNA in serum and seroconversion of HBsAg
Virological Response = Undetectable HDV RNA in serum