TABLE 1.

Grades of Infusion Site Reactions

Grade	Definition
1	Tenderness with or without associated symptoms (e.g., warmth, erythema, itching)
2	Pain at access site, lipodystrophy and/or edema and/or phlebitis
3	Ulceration or necrosis, severe tissue damage; operative intervention needed
4	Life-threatening consequences; urgent intervention indicated
5	Death

Note. From Common Terminology Criteria for Adverse Events [v.4.03], by National Cancer Institute Cancer Therapy Evaluation Program, 2010. Retrieved from http://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf