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. 2017 Apr 7;46(6):1734–1739. doi: 10.1093/ije/dyx034

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© The Author 2017. Published by Oxford University Press on behalf of the International Epidemiological Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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A. Code and output from implementation of MR-Egger method using mr_egger() function for analysis of causal effect of high-density lipoprotein-cholesterol (HDL-c) on coronary heart disease (CHD) risk. B. Output from mr_plot() function applied to mr_input() object. Screenshot of interactive graph illustrating genetic associations with CHD risk (log odds ratios) against genetic associations with HDL-c (in standard deviation units) with error bars representing 95% confidence intervals for the associations. The variants are all orientated to the HDL-c-increasing allele. The line represents the MR-Egger causal estimate. One of the genetic variants is highlighted by mousing over. The infobox gives the name of the variant (snp_16), and its associations with the exposure and with the outcome. STD, standard.