Skip to main content
. Author manuscript; available in PMC: 2018 Mar 21.
Published in final edited form as: Immunity. 2017 Mar 21;46(3):379–392. doi: 10.1016/j.immuni.2017.02.017

Figure 2. Structure of the IFN-λ Ternary Complex.

Figure 2

(A) The structure of the ternary complex reveals the mechanism of IL-10Rβ (gold) recognition of IFN-λ3 H11 (blue) and IFN-λR1 (gray). The IL-10Rβ makesextensive and continuous contacts with H11 at sites 2a and 2b, and site 3 makes stem-stem contacts with the IFN-λR1. Unique to the IFN-λ structure, a largesurface area of the cytokine remains surface exposed in the ternary complex.

(B) Structure of the IL-10/IL-10R1 partial signaling complex (PDB: 1J7V) (Josephson et al., 2001).

(C) Structure of a type I IFN receptor complex (PDB: 3SE4) (Thomas et al., 2011). See also Table S1.