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. Author manuscript; available in PMC: 2018 Mar 21.
Published in final edited form as: Immunity. 2017 Mar 21;46(3):379–392. doi: 10.1016/j.immuni.2017.02.017

Figure 3. Specific Interactions Mediating the Stability of the Ternary Complex.

Figure 3

For a Figure360 author presentation of Figure 3, see http://dx.doi.org/10.1016/j.immuni.2017.02.017#mmc3.

(A) Overview of the IFN-λ3 H11 (blue)/IFN-λR1 (gray)/IL-10Rβ (gold) ternary complex.

(B) Detailed views of the site 2a and site 2b contacts between IFN-λ3 H11 and IL-10Rβ tyrosines 59, 82, and 140. Hydrogen bonds are indicated by dashedblack lines.

(C) Shared receptor use of aromatic residues to bind cytokines.

(D) IL-10Rβ uses Tyr82 residue as a hotspot of binding like other shared receptor systems.

(E) Y103 of γc bound to IL-2 (PDB: 3QAZ) (Levin et al., 2012).

(F) F169 of gp130 bound to IL-6 (PDB: 1P9M) (Boulanger et al., 2003b). See also Figure S2.