Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 May 1;2(1):87–95. doi: 10.1089/can.2016.0032

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© John M. McPartland et al. 2017; Published by Mary Ann Liebert, Inc.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Mary Ann Liebert, Inc. offers reprint services for those who want to order professionally produced copies of articles published under the Creative Commons Attribution (CC BY) license. To obtain a price quote, email Reprints@liebertpub.com. Please include the articlés title or DOI, quantity, and delivery destination in your email.

PMC Copyright notice

FIG. 4. — Efficacy of THCA-A and THC in cAMP assays, CB₁ on the left, CB₂ on the right. (A–D) Show representative images of the biosensor traces of single experiments carried out in duplicate. (A, B) Show that THC (10 μM) inhibits cAMP at both CB₁ (left) and CB₂ (right). (C, D) Show the same assay carried out with THCA-A. THCA-A can be seen to inhibit forskolin mediated cAMP alone and to partially antagonize the ability of CP55,940 to inhibit cAMP at CB₁, but has no effect under equivalent conditions at CB₂. The lower panels (E, F) are summary data for the area under the curve analyses for all replicate assays combined (n=5 for CB₁ or n=6 for CB₂). *p=0.0065 by paired t-test, n=5. ^#p=0.015 t-test compared to 100%. cAMP, cyclic adenosine monophosphase.