FIG. 2.

Changes in response waveform post-TBI in area CA1 and dentate gyrus. Representative examples of responses to stimuli in the Schaffer collaterals (CA1) or medial perforant path (mPP) and lateral performant path (lPP) in hippocampal slices after rotational brain injury in swine. Each waveform is the average of 10 traces at the half-maximal stimulation. Note the profound disruption in the EPSP post-injury in area CA1 and in the dentate when stimulating the mPP (arrows). A distinct pattern commonly appears in the waveforms post-injury that may be due to the population activity response invading the EPSP, suggesting hyper-excitability in the neuronal response.