Table 3. Five-year observed overall survival (OS) and results from Cox regression analysis in patients with glottic LSCC during 15-years' follow-up.
| No. at risk | No. of failures during 15-years | Five-year observed OS | Univariate | Multivariate | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % | 95% CI | HR | 95% CI | P value | HR | 95% CI | P value | ||||||
| Gender | |||||||||||||
| Male | 1,022 | 362 | 62.9 | 59.8 | 65.9 | 1 | 1 | ||||||
| Female | 105 | 25 | 75.3 | 65.7 | 82.7 | 0.75 | 0.56 | 0.99 | 0.05 | 0.84 | 0.60 | 1.20 | 0.34 |
| Age (years) | |||||||||||||
| 0–59 | 313 | 63 | 78.8 | 73.8 | 83.1 | 1 | 1 | ||||||
| 60–69 | 383 | 122 | 66.6 | 61.5 | 71.2 | 2.06 | 1.64 | 2.58 | <0.001 | 2.22 | 1.72 | 2.86 | <0.001 |
| 70+ | 431 | 202 | 50.8 | 45.8 | 55.7 | 3.82 | 3.08 | 4.75 | <0.001 | 4.36 | 3.38 | 5.62 | <0.001 |
| Smoking history | |||||||||||||
| Never | 74 | 24 | 65.5 | 52.9 | 75.5 | 1 | 1 | ||||||
| Ever | 995 | 340 | 64.2 | 61.1 | 67.2 | 1.20 | 0.86 | 1.66 | 0.28 | 1.38 | 0.85 | 2.25 | 0.19 |
| Unknown | 58 | 23 | 58.5 | 44.3 | 70.2 | ||||||||
| Alcohol | |||||||||||||
| Never | 635 | 205 | 66.1 | 62.1 | 69.7 | 1 | 1 | ||||||
| Ever | 126 | 67 | 46.0 | 37.0 | 54.5 | 1.59 | 1.27 | 1.99 | <0.001 | 1.65 | 1.29 | 2.10 | <0.001 |
| Unknown | 366 | 115 | 66.7 | 61.5 | 71.5 | ||||||||
| T-status | |||||||||||||
| T1a | 551 | 124 | 75.7 | 71.7 | 79.2 | 1 | 1 | ||||||
| T1b | 44 | 13 | 68.4 | 51.7 | 80.3 | 1.15 | 0.77 | 1.72 | 0.49 | 0.92 | 0.55 | 1.53 | 0.75 |
| T2 | 248 | 86 | 64.5 | 58.1 | 70.2 | 1.44 | 1.19 | 1.75 | <0.001 | 1.10 | 0.83 | 1.45 | 0.50 |
| T3 | 138 | 82 | 36.7 | 28.3 | 45.1 | 2.72 | 2.17 | 3.41 | 0.001 | 2.08 | 1.51 | 2.86 | <0.001 |
| T4 | 146 | 82 | 42.9 | 34.7 | 50.9 | 2.54 | 2.03 | 3.16 | <0.001 | 2.23 | 1.48 | 3.38 | <0.001 |
| N-status | |||||||||||||
| N0 | 1,050 | 331 | 66.8 | 63.8 | 69.6 | 1 | 1 | ||||||
| N1 | 33 | 23 | 30.3 | 15.9 | 46.1 | 2.28 | 1.55 | 3.35 | <0.001 | 1.38 | 0.87 | 2.21 | 0.17 |
| N2+ | 44 | 33 | 23.6 | 12.1 | 37.2 | 4.09 | 2.95 | 5.68 | <0.001 | 1.66 | 1.10 | 2.51 | 0.01 |
| Stage I-IV | |||||||||||||
| I | 593 | 136 | 75.3 | 71.4 | 78.7 | 1 | |||||||
| II | 239 | 79 | 66.1 | 59.6 | 71.8 | 1.39 | 1.14 | 1.68 | <0.01 | ||||
| III | 133 | 78 | 37.5 | 28.9 | 46.1 | 2.57 | 2.05 | 3.23 | <0.001 | ||||
| IV | 162 | 94 | 40.9 | 33.1 | 48.5 | 2.66 | 2.16 | 3.28 | <0.001 | ||||
| Treatment | |||||||||||||
| Radiotherapy | 675 | 257 | 61.2 | 57.4 | 64.8 | 1 | 1 | ||||||
| Transoral laser microsurgery | 318 | 60 | 78.1 | 72.6 | 82.6 | 0.55 | 0.45 | 0.69 | <0.001 | 0.69 | 0.48 | 0.99 | 0.04 |
| Total laryngectomy | 102 | 47 | 53.1 | 42.9 | 62.4 | 1.29 | 1.01 | 1.64 | 0.04 | 0.62 | 0.42 | 0.93 | 0.02 |
| Chemo- radiotherapy | 16 | 7 | 44.1 | 15.4 | 69.8 | 1.39 | 0.66 | 2.94 | 0.39 | 1.15 | 0.51 | 2.61 | 0.74 |
| Palliation/ no treatment |
16 | 16 | - | - | - | 30.7 | 18.0 | 52.2 | <0.001 | 31.5 | 14.2 | 69.8 | <0.001 |
| Period of treatment | |||||||||||||
| 1983–1989 | 293 | 107 | 63.5 | 57.7 | 68.7 | 1 | 1 | ||||||
| 1990–1996 | 249 | 83 | 66.7 | 60.4 | 72.1 | 0.84 | 0.69 | 1.02 | 0.09 | 0.95 | 0.74 | 1.21 | 0.68 |
| 1997–2003 | 287 | 109 | 62.0 | 56.1 | 67.4 | 0.99 | 0.81 | 1.20 | 0.91 | 1.16 | 0.88 | 1.53 | 0.28 |
| 2004–2010 | 298 | 88 | 63.8 | 57.0 | 69.8 | 0.97 | 0.76 | 1.24 | 0.82 | 1.26 | 0.91 | 1.75 | 0.16 |