Table 4. Five-year observed overall survival (OS) and results from Cox regression analysis of patients with supraglottic LSCC during 15-years' follow-up.
| No. at risk | No. of failures during 15-years | Five-year observed OS | Univariate | Multivariate | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % | 95% CI | HR | 95% CI | P value | HR | 95% CI | P value | ||||||
| Gender | |||||||||||||
| Male | 341 | 205 | 38.5 | 33.3 | 43.8 | 1 | 1 | ||||||
| Female | 97 | 53 | 38.6 | 28.0 | 49.1 | 0.98 | 0.75 | 1.27 | 0.86 | 0.94 | 0.70 | 1.27 | 0.68 |
| Age (years) | |||||||||||||
| 0–59 | 129 | 59 | 52.9 | 43.7 | 61.2 | 1 | 1 | ||||||
| 60–69 | 142 | 87 | 36.4 | 28.3 | 44.6 | 1.58 | 1.18 | 2.11 | <0.01 | 1.95 | 1.40 | 2.72 | <0.001 |
| 70+ | 167 | 112 | 29.8 | 22.8 | 37.1 | 2.02 | 1.53 | 2.69 | <0.001 | 2.69 | 1.95 | 3.71 | <0.001 |
| Smoking history | |||||||||||||
| Never | 22 | 15 | 29.2 | 12.0 | 48.9 | 1 | |||||||
| Ever | 394 | 224 | 40.7 | 35.6 | 45.7 | 1.20 | 0.86 | 1.66 | 0.28 | ||||
| Unknown | 22 | 19 | 13.6 | 34.1 | 30.9 | ||||||||
| Alcohol | |||||||||||||
| Never | 272 | 147 | 44.1 | 38.0 | 50.0 | 1 | 1 | ||||||
| Ever | 87 | 51 | 25.7 | 16.5 | 36.0 | 1.59 | 1.27 | 1.99 | <0.001 | 1.50 | 1.10 | 2.05 | 0.01 |
| Unknown | 79 | 50 | 33.9 | 23.4 | 44.7 | ||||||||
| T-status | |||||||||||||
| T1 | 65 | 37 | 40.0 | 27.7 | 52.0 | 1 | 1 | ||||||
| T2 | 123 | 61 | 47.0 | 37.5 | 55.9 | 0.83 | 0.56 | 1.18 | 0.30 | 0.87 | 0.57 | 1.34 | 0.53 |
| T3 | 84 | 46 | 42.9 | 31.8 | 53.5 | 0.94 | 0.64 | 1.37 | 0.74 | 0.83 | 0.52 | 1.31 | 0.42 |
| T4 | 166 | 114 | 30.3 | 23.4 | 37.5 | 1.35 | 0.98 | 1.87 | 0.007 | 1.14 | 0.75 | 1.75 | 0.53 |
| N-status | |||||||||||||
| N0 | 249 | 119 | 50.3 | 43.8 | 56.5 | 1 | 1 | ||||||
| N1 | 64 | 40 | 35.9 | 24.0 | 47.8 | 1.45 | 1.06 | 1.98 | 0.02 | 1.29 | 0.90 | 1.86 | 0.17 |
| ≥N2 | 125 | 99 | 16.1 | 9.8 | 23.7 | 2.69 | 2.10 | 3.46 | <0.001 | 2.32 | 1.70 | 3.18 | <0.001 |
| Stage I–IV | |||||||||||||
| I | 51 | 26 | 45.9 | 31.4 | 59.3 | 1 | |||||||
| II | 77 | 29 | 60.2 | 48.0 | 70.5 | 0.70 | 0.45 | 1.08 | 0.11 | ||||
| III | 81 | 40 | 48.5 | 36.9 | 59.2 | 0.89 | 0.59 | 1.36 | 0.61 | ||||
| IV | 229 | 163 | 26.3 | 20.6 | 32.3 | 1.66 | 1.17 | 2.36 | <0.01 | ||||
| Treatment | |||||||||||||
| Radiotherapy | 301 | 164 | 43.5 | 37.6 | 49.2 | 1 | 1 | ||||||
| Transoral laser microsurgery | 13 | 7 | 41.0 | 13.8 | 66.9 | 1.22 | 0.63 | 2.69 | 0.55 | 1.97 | 0.83 | 4.66 | 0.12 |
| Total laryngectomy | 61 | 36 | 39.9 | 27.9 | 51.9 | 1.04 | 0.78 | 1.42 | 0.79 | 0.88 | 0.60 | 1.28 | 0.51 |
| Chemo-radiotherapy | 39 | 27 | 20.3 | 8.0 | 36.6 | 1.55 | 1.06 | 2.27 | 0.03 | 1.56 | 1.00 | 2.43 | 0.05 |
| Palliation/no treatment | 24 | 24 | - | - | - | 9.64 | 6.12 | 14.9 | <0.001 | 6.44 | 3.70 | 11.3 | <0.001 |
| Period of treatment | |||||||||||||
| 1983–1989 | 100 | 59 | 41.0 | 31.3 | 50.4 | 1 | 1 | ||||||
| 1990–1996 | 119 | 74 | 37.8 | 29.2 | 46.4 | 1.05 | 0.79 | 1.41 | 0.72 | 1.03 | 0.73 | 1.46 | 0.85 |
| 1997–2003 | 104 | 64 | 38.5 | 29.2 | 47.7 | 1.03 | 0.76 | 1.40 | 0.82 | 1.20 | 0.84 | 1.73 | 0.31 |
| 2004–2010 | 115 | 41 | 38.9 | 28.5 | 49.1 | 1.06 | 0.75 | 1.48 | 0.75 | 0.96 | 0.64 | 1.45 | 0.85 |