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Two mechanisms associated with the transition from the anti-syn conformation to the anti-anti conformation. (a) The transition occurs through base flipping in the major groove. The structure goes from B1 to A3 to A1. (b) The transition occurs through base flipping in the minor groove. The insets show the A-A conformation in the vertical direction. See detailed descriptions in the text. To see this figure in color, go online.
