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. 2017 Jul 14;12(7):e0180920. doi: 10.1371/journal.pone.0180920

Table 1. Hospitalizations, mechanical ventilation and fatal cases in seasonal influenza waves and the 2009 pandemic.

Hospitalizations
Seasonal Flu Pandemic Flu Pandemic vs. Seasonal
Gender N (% All) Hospitalization Rate N (% All) Hospitalization Rate unadj. OR (CI) p-value
Female 9,704 (46.6) 3.38 6,554 (47.9) 15.96 1.05 (1.01–1.1) 0.0235
Male 11,102 (53.4) 4.05 7,133 (52.1) 18.22 0.95 (0.91–0.99)
Age Group
0–4 6,328 (30.4) 27.07 2,989 (21.8) 89.52 0.64 (0.61–0.67) < 0.0001
5–14 4,623 (22.2) 8.85 3,566 (26.1) 47.76 1.23 (1.17–1.3) < 0.0001
15–34 3,078 (14.8) 2.38 3,500 (25.6) 18.95 1.98 (1.87–2.09) < 0.0001
35–59 3,614 (17.4) 1.74 2,711 (19.8) 9.12 1.17 (1.11–1.24) < 0.0001
> 60 3,163 (15.2) 2.13 921 (6.7) 4.34 0.40 (0.37–0.43) < 0.0001
All 20,806 (100) 3.71 13,687 (100) 17.06
Mechanical Ventilation
N (% All)
Seasonal Flu Pandemic Flu Pandemic vs. Seasonal
Gender N (% All) MV Rate (%) N (% All) MV Rate (%) unadj. OR (CI) p-value
Female 651 (63.2) 6.71 356 (58.1) 5.43 0.8 (0.7–0.91) 0.0009
Male 379 (36.8) 3.41 257 (41.9) 3.6 1.06 (0.89–1.25) 0.4968
Age Group
0–4 100 (9.7) 1.58 39 (6.4) 1.3 0.82 (0.57–1.2) 0.3059
5–14 39 (3.8) 0.84 31 (5.1) 0.87 1.03 (0.64–1.66) 0.9003
15–34 118 (11.5) 3.83 125 (20.4) 3.57 0.93 (0.72–1.2) 0.5737
35–59 463 (45) 12.81 302 (49.3) 11.14 0.85 (0.73–0.99) 0.0436
> 60 310 (30.1) 9.8 116 (18.9) 12.6 1.33 (1.06–1.66) 0.0146
All 1,030 (100) 4.95 613 (100) 4.48 0.9 (0.81–1) 0.0441
Fatal Cases
N (% All)
Seasonal Flu Pandemic Flu Pandemic vs. Seasonal
Gender N (% All) Fatality Rate (%) N (% All) Fatality Rate (%) unadj. OR (CI) p-value
Female 362 (62.5) 3.73 168 (57.3) 2.56 0.68 (0.56–0.82) <0.0001
Male 217 (37.5) 1.95 125 (42.7) 1.75 0.89 (0.72–1.12) 0.326
Age Group
0–4 26 (4.5) 0.41 9 (3.1) 0.3 0.73 (0.34–1.56) 0.4188
5–14 24 (4.1) 0.52 18 (6.1) 0.5 0.97 (0.53–1.79) 0.928
15–34 48 (8.3) 1.56 37 (12.6) 1.06 0.67 (0.44–1.04) 0.0719
35–59 219 (37.8) 6.06 145 (49.5) 5.35 0.88 (0.71–1.09) 0.2294
> 60 262 (45.3) 8.28 84 (28.7) 9.12 1.11 (0.86–1.44) 0.422
All 579 (100) 2.78 293 (100) 2.14 0.76 (0.66–0.88) 0.0002

The upper panel shows total hospitalizations (N) for different age groups and both sexes. Age and gender proportions are given in parentheses (% of all). The hospitalization rate is given as cases per 100,000 persons per season, of each respective subpopulation. The unadjusted odds (OR) of hospitalization are given to compare seasonal and pandemic influenza. P-values and 95% confidence intervals are given. The middle panel shows the absolute number of patients requiring mechanical ventilation (MV). The age- and gender-specific proportions are given in parentheses (% of all). The age- and gender-specific rates of mechanical ventilation (MV rate) were calculated in relation to the respective group of all hospitalizations. The given odds ratios compare age- and gender-specific MV rates. P-values and 95% confidence intervals are given. The lower panel shows the absolute number of fatal cases for different age groups and both sexes (N). Age- and gender-specific proportions among fatal cases are given in parentheses (% of all). The age- and gender-specific fatality rate is given. The given odds ratios are to compare age- and gender-specific fatality rates. P-values and 95% confidence intervals are given.