Table 1. Factors that may determine the selection of a SMILE enhancement technique over the other.

	SA+MMC	S+SE	S+C	SCLE
Enhancement correction required	Any	≥ -1.00D	Any	Any
Depth of primary SMILE cap	Any	≥140 μm	≤120 μm	≤130 μm
Post-primary SMILE residual stromal bed thickness	Any	>250 μm	≥300 μm	>250 μm
Hyperopic or myopic enhancement	Both	Myopic only	Both	Myopic only
Flap or maintain flap-less	Flap-less	Flap-less	Flap	Flap-less
Wound recovery time	Slow	Fast	Intermediate	Fast

SA = surface ablation

MMC = mitomycin C

S+SE = new SMILE anterior to previous SMILE procedure

S+C = flap creation by VisuMax Circle, followed by excimer stromal ablation

SCLE = sub-cap lenticule extraction (described by Donate et al. [33])