Table 2. Risk of meningioma in relation to diabetes status, duration of diabetes, and HbA1c level, overall and stratified by sex and age.
| Variable | Number of cases (%) n = 2,027 | Number of controls (%) n = 20,269 | Adjusted ORa (95%CI) |
|---|---|---|---|
| Total meningioma | |||
| Diabetes | 145 (7.2) | 1,465 (7.2) | 0.89 (0.74–1.07) |
| Women | |||
| Diabetes | 90 (5.9) | 1,001 (6.5) | 0.78 (0.62–0.98) |
| Men | |||
| Diabetes | 55 (11.2) | 464 (9.4) | 1.17 (0.85–1.61) |
| <40 years | |||
| Diabetes | 0 (0.0) | 18 (1.1) | n.e. |
| 40–69 years | |||
| Diabetes | 64 (5.6) | 592 (5.1) | 0.93 (0.70–1.23) |
| >69 years | |||
| Diabetes | 81 (11.3) | 855 (12.0) | 0.88 (0.68–1.29) |
| Total glioma | |||
| Duration of Diabetes | |||
| Non-diabetic | 1,882 (92.9) | 18,804 (92.8) | 1.00 (referent) |
| < 2 years | 24 (1.2) | 229 (1.1) | 0.93 (0.61–1.42) |
| 2–5 years | 32 (1.6) | 375 (1.9) | 0.75 (0.52–1.08) |
| > 5 years | 89 (4.4) | 861 (4.3) | 0.94 (0.74–1.18) |
| p-value for trend | 0.423 | ||
| HbA1c level | |||
| Unknown | 1,858 (91.7) | 18,700 (92.3) | 1.05 (0.83–1.31) |
| < 6.5% | 96 (4.7) | 927 (4.6) | 1.00 (referent) |
| 6.5–7.9% | 40 (2.0) | 314 (1.6) | 1.19 (0.81–1.77) |
| ≥ 8.0% | 33 (1.6) | 328 (1.6) | 0.97 (0.64–1.47) |
| p-value for trend | 0.977 | ||
aMatched on age, sex, general practice, and number of years of active history in the database, and adjusted for BMI, smoking, arterial hypertension, MI, and use of estrogens.
The p-value for trend did not include subjects with unknown HbA1c level.