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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Genet Epidemiol. 2017 Apr 10;41(5):388–395. doi: 10.1002/gepi.22044

Table 3.

Comparison of the Firth and BinomiRare tests performed on the HCHS/SOL cohort of uncorrelated individuals, in pooled analysis of all individuals, and in meta-analyzing the six genetic analysis groups. λgc is the inflation factor, “cor W Firth pooled” is the correlation between the p-values in the Firth analysis on the pooled data set and the test in question, and rs13401266 (chr2:143070709, 71 carriers, 25 diseased) and rs13421020 (chr2:143074067, 72 carriers, 25 diseased) pval are the p-values of these variants in each of the analyses.

Test λgc cor w Firth pooled rs13401266 pval rs13421020 pval
Firth pooled 1.00 – 6.05×10−7 9.94×10−7
Firth meta 0.65 0.37 4.17×10−6 6.12 ×10−6
BR pooled 0.91 0.94 2.38×10−7 2.70×10−7
BR meta 0.91 0.94 2.38×10−7 2.70×10−7