Fig 7. Both Dectin-2 and Dectin-1 and downstream signals regulate dendritic cell release of cathepsin B.

BMDCs from wild type, Clec7a^-/-, Clec4n^-/- and Clec7a^-/-Clec4n^-/- mice. (A) Cells were stimulated with H. capsulatum. Cell lysates and supernatants were harvested 18 h later and subjected to cathepsin B activity assay (n = 3). (B) Cells were treated with or without ERK (U1026) and JNK (SP600125) inhibitor before stimulation with H. capsulatum for 18 h. Cell lysates and supernatants were harvested and subjected to cathepsin B activity assay (n = 3). Error bars indicate standard deviation of the mean. * p < 0.05, ** p < 0.01, *** p < 0.001, NS, not significant [one-way ANOVA with Tuckey post-hoc analysis (A) or Sidak post-hoc analysis (B)].