. Author manuscript; available in PMC: 2017 Aug 1.

Published in final edited form as: Dev Psychopathol. 2016 Jul 18;29(3):901–917. doi: 10.1017/S0954579416000560

Table 3.

The interaction of prenatal maternal depression and child multilocus genetic profile score (5-HTTLPR and DRD4) in the prediction of Negative Emotionality at 3, 6, 18 and 36 months (confirmatory regression)

Predictors	3 months β	6 months B	18 months B	36 months B
Intercept	−0.445^**	−0.362^**	−0.215^t	−0.145
Cross-over point^a	20.043^***	11.68^*	−11.362	4.108
Interaction	0.013^**	0.013^*	0.002	0.014^**
Covariates
Postnatal depression	-	0.005	0.02^***	0.018^***
Maternal education – College	0.238^t	0.302^*	0.218^t	0.07
Maternal education – University	0.333^*	0.205^t	0.133	0.047
Gender	0.099	0.136^t	−0.088	−0.054
Mother age of birth	−0.012	−0.026^**	−0.025^**	−0.015
Site	0.318^***	0.112	−0.012	−0.02
Maternal 5-HTTLPR	−0.263^*	−0.153^t	−0.032	−0.005

Note. Multilocus genetic profile score - 0, 1 or 2 risk/susceptibility genotype (no L_A (S/S, S/L_G or L_G/L_G)(5-HTTLPR); 6–8R (DRD4)). At 3 months R² = .24, F(8, 123) = 4.86***, at 6 months R² = .18, F(9, 157) = 3.91***, at 18 months R² = .20, F(9, 152) = 4.33***, and at 36 months R² = .20, F(9, 169) = 4.61***.

Strong differential susceptibility models are indicated by statistically significant cross over points at 3 and 6 months.

p < .10

p < .05

^**

p < .01

^***

p < .001