Figure 2. Concordance of a pancreatic neuroendocrine tumor detected on a fine needle aspirate (A–C) and on the resected specimen (D–F).
DAXX with retained nuclear expression (A, D), ATRX with loss of nuclear expression (B, E), and telomere-specific FISH to detect ALT (C, F). Arrows highlight cells with ultra-bright telomeric DNA foci indicative of ALT (DAPI nuclear counterstain). All images were taken at × 400 original magnification.