Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1980 Jul;29(1):271–274. doi: 10.1128/iai.29.1.271-274.1980

Identification of a cytotoxin produced by Legionella pneumophila.

R L Friedman, B H Iglewski, R D Miller
PMCID: PMC551106  PMID: 6995339

Abstract

Culture filtrates of Legionella pneumophila were cytotoxic for Chinese hamster ovary cells. The cytotoxin was found to be methanol soluble, heat stable, and stable from pH 5 through 8.

Full text

PDF
271

Images in this article

273Fig. 1
on p.273

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baine W. B., Rasheed J. K., Mackel D. C., Bopp C. A., Wells J. G., Kaufmann A. F. Exotoxin activity associated with the Legionnaires disease bacterium. J Clin Microbiol. 1979 Mar;9(3):453–456. doi: 10.1128/jcm.9.3.453-456.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Blackmon J. A., Hicklin M. D., Chandler F. W. Legionnaires' disease. Pathological and historical aspects of a 'new' disease. Arch Pathol Lab Med. 1978 Jul;102(7):337–343. [PubMed] [Google Scholar]
  3. Chandler F. W., Hicklin M. D., Blackmon J. A. Demonstration of the agent of Legionnaires' disease in tissue. N Engl J Med. 1977 Dec 1;297(22):1218–1220. doi: 10.1056/NEJM197712012972206. [DOI] [PubMed] [Google Scholar]
  4. Fraser D. W., Tsai T. R., Orenstein W., Parkin W. E., Beecham H. J., Sharrar R. G., Harris J., Mallison G. F., Martin S. M., McDade J. E. Legionnaires' disease: description of an epidemic of pneumonia. N Engl J Med. 1977 Dec 1;297(22):1189–1197. doi: 10.1056/NEJM197712012972201. [DOI] [PubMed] [Google Scholar]
  5. Friedman H. M. Legionnaires' disease in non-Legionnaires. A report of five cases. Ann Intern Med. 1978 Mar;88(3):294–302. doi: 10.7326/0003-4819-88-3-294. [DOI] [PubMed] [Google Scholar]
  6. Iglewski B. H., Sadoff J. C. Toxin inhibitors of protein synthesis: production, purification, and assay of Pseudomonas aeruginosa toxin A. Methods Enzymol. 1979;60:780–793. doi: 10.1016/s0076-6879(79)60071-x. [DOI] [PubMed] [Google Scholar]
  7. McDade J. E., Shepard C. C., Fraser D. W., Tsai T. R., Redus M. A., Dowdle W. R. Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N Engl J Med. 1977 Dec 1;297(22):1197–1203. doi: 10.1056/NEJM197712012972202. [DOI] [PubMed] [Google Scholar]
  8. Müller H. E. Proteolytic action of Legionella pneumophila on human serum proteins. Infect Immun. 1980 Jan;27(1):51–53. doi: 10.1128/iai.27.1.51-53.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Warren W. J., Miller R. D. Growth of Legionnaires disease bacterium (Legionella pneumophila) in chemically defined medium. J Clin Microbiol. 1979 Jul;10(1):50–55. doi: 10.1128/jcm.10.1.50-55.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Winn W. C., Jr, Glavin F. L., Perl D. P., Keller J. L., Andres T. L., Brown T. M., Coffin C. M., Sensecqua J. E., Roman L. N., Craighead J. E. The pathology of Legionnaires' disease. Fourteen fatal cases from the 1977 outbreak in Vermont. Arch Pathol Lab Med. 1978 Jul;102(7):344–350. [PubMed] [Google Scholar]
  11. Wong K. H., Moss C. W., Hochstein D. H., Arko R. J., Schalla W. O. "Endotoxicity" of the Legionnaires' disease bacterium. Ann Intern Med. 1979 Apr;90(4):624–627. doi: 10.7326/0003-4819-90-4-624. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES