Table 3.
Fluid Balance and Risk-adjusted One Year Mortality
| Population | Fluid Balance | Adjusted Hazard Ratio (95%CI) by Time Interval in Days$,* | P value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| All subjects (n=18,084) |
5–11 | 11–21 | 21–42 | 42–88 | 88–178 | 178–365 | |||
|
|
|||||||||
| Negative vs Even | 0.81 (0.68–0.96) |
0.91 (0.78–1.06) |
1.01 (0.88–1.16) |
1.12 (0.98–1.28) |
1.16 (1.01–1.32) |
1.22 (1.05–1.42) |
0.004 | ||
| Positive vs Even | 1.68 (1.46–1.93) |
1.92 (1.69–2.17) |
1.86 (1.66–2.09) |
1.77 (1.58–1.98) |
1.61 (1.43–1.81) |
1.30 (1.14–1.49) |
<0.001 | ||
| Negative vs Positive | 0.48 (0.41–0.56) |
0.51 (0.49–0.58) |
0.56 (0.50–0.63) |
0.64 (0.57–0.72) |
0.73 (0.65–0.82) |
0.84 (0.74–0.97) |
<0.001 | ||
|
| |||||||||
| RRT subgroup (n=1,545) |
5–11 | 11–17 | 17–25 | 25–38 | 38–62 | 62–127 | 127–365 | ||
|
|
|||||||||
| Negative vs Even | 0.88 (0.52–1.50) |
0.99 (0.62–1.57) |
0.89 (0.58–1.39) |
0.93 (0.60–1.43) |
1.13 (0.72–1.76) |
1.10 (0.68–1.79) |
0.91 (0.52–1.59) |
0.889 | |
| Positive vs Even | 0.86 (0.65–1.14) |
0.95 (0.75–1.22) |
1.16 (0.92–1.46) |
1.07 (0.85–1.35) |
1.03 (0.80–1.31) |
1.19 (0.91–1.55) |
1.23 (0.90–1.68) |
0.230 | |
|
| |||||||||
| Non-RRT subgroup (n=16,539) |
5–11 | 11–22 | 22–47 | 47–100 | 100–192 | 192–365 | |||
|
|
|||||||||
| Negative vs Even | 0.82 (0.69–0.97) |
0.93 (0.80–1.08) |
1.04 (0.91–1.19) |
1.11 (0.97–1.27) |
1.14 (0.99–1.31) |
1.20 (1.03–1.40) |
0.01 | ||
| Positive vs Even | 1.62 (1.40–1.87) |
1.87 (1.65–2.12) |
1.83 (1.63–2.06) |
1.65 (1.47–1.86) |
1.51 (1.34–1.71) |
1.25 (1.08–1.44) |
<0.001 | ||
|
| |||||||||
| Non-AKI subgroup (n=6,098) |
5–13 | 13–42 | 42–90 | 90–160 | 160–260 | 260–365 | |||
|
|
|||||||||
| Negative vs Even | 1.00 (0.73–1.36) |
1.00 (0.77–1.31) |
1.24 (0.97–1.59) |
1.41 (1.1–1.79) |
1.31 (1.02–1.69) |
1.10 (0.82–1.48) |
0.064 | ||
| Positive vs Even | 1.62 (1.20–2.18) |
1.49 (1.15–1.93) |
1.41 (1.10–1.80) |
1.47 (1.14–1.88) |
1.24 (0.95–1.62) |
1.06 (0.78–1.45) |
0.002 | ||
Shown are adjusted hazard ratios (AHR) estimated from Gray’s model (20) for association between FB and mortality for each time interval. Models for all subjects, non-RRT, and non-AKI subgroups included six time intervals and five time nodes. Whereas, RRT subgroup included seven time intervals and six time nodes. For each of the above models, the default timing of nodes is chosen by the statistical program based on number of observations within each time interval. A hazard ratio < 1 suggests that FB is associated with lower mortality and a hazard ratio > 1 suggests FB is associated with higher mortality. P values reported are for the ranges of hazard ratios from the model.
Adjusted for age, race, baseline serum creatinine, body mass index, comorbidities, cardiac disease, heart failure, liver disease and associated sequelae, liver transplant, malignancy, surgery, admission APACHE-III score, vasopressor use, mechanical ventilation use, suspected sepsis, and hypotensive index, oliguria, acute kidney injury stratified according KDIGO guidelines (17) and RRT use (except in the RRT subgroup)