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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Physiol Behav. 2017 Jan 14;178:82–92. doi: 10.1016/j.physbeh.2017.01.020

Fig. 2.

Fig. 2

Effects of CORT 118335 on hormonal stress response in male rats. (A) Males treated with CORT 118335 at 10 mg/kg and 30 mg/kg displayed dose-dependent attenuated corticosterone levels in response to restraint stress (15 min–60 min from restraint onset) without delaying HPA axis shut off at 120 min. (B) Both doses significantly decreased integrated corticosterone response to restraint stress. (C) Males treated with CORT 118335 at both 10 mg/kg and 30 mg/kg displayed attenuated corticosterone levels in response to FST stress (15 min–30 min from FST onset) without delaying HPA axis shut off at 90 min. At 90 min, the corticosterone level for CORT 118335 at 30 mg/kg was still significantly lower compared to vehicle controls and also to the 10 mg/kg dose. (D) Both doses significantly decreased integrated corticosterone response to FST stress. Values represent mean ± SEM; n = 10 per group for corticosterone time course analyses; n = 7–9 per group for AUC analyses. * indicates significant effect compared to all vehicle treated animals only (p ≤ 0.05); # indicates significant effect compared to all other groups (p ≤ 0.05).