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FTY720 treatment decreased skeletal muscle EBD uptake. Total EBD uptake was reduced in both wild-type and Sgcg mutant animals by FTY720 treatment (A) (averages and standard errors). After correcting for FTY720-reduced endothelial cell permeability by normalizing to kidney EBD uptake, the treated Sgcg animals had significantly less EBD uptake (B). WT + DMSO, N = 5; WT+FTY, N = 5; Sgcg+DMSO, N = 11; Sgcg+FTY, N = 14. Thick black bars indicate ANOVA, P < 0.05.
