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. 2017 Jun 29;9(1):217–230. doi: 10.1016/j.stemcr.2017.05.030

Figure 7.

Figure 7

Enhanced Expression of Reelin Resulting from BACE1 Deficiency

(A–F) Confocal staining of brain sections showed restricted expression of reelin by Cajal-Retzius cells located in the MZ at P3, P7, and P20. Scale bars, 50 μm.

(G) Numbers of reelin+ cells were counted from each captured image in three age groups, and average numbers of reelin+ cells per DG section were used for comparison (n = 5 pairs of mice, Student's t test).

(H) Western blotting of hippocampal lysates showed that expression of reelin in hippocampi gradually decreased after birth.

(I) Bar graphs show the relative levels of reelin over β-actin. Quantification was performed from three independent experiments (n = 6 pairs of P6, 8 pairs of P20, and 6 pairs of P30 mice; ∗p < 0.05, ∗∗p < 0.01). Reelin upregulation potentially arrests the migration of neuroprogenitor cells and may lead to the formation of neuronal clusters in DG of BACE1-null mice.