Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 14;7:5454. doi: 10.1038/s41598-017-05707-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Elevated netrin-1 expression was positively correlated with cell proliferation in glioma tissue specimens. (a) Representative images of netrin-1 staining by IHC in glioma cancer sections. Boxed areas in the upper panels were magnified and are shown in the corresponding lower panels. Red arrowheads indicated examples of cells with positive netrin-1 staining. Scale bar: 50 μm. (b) Relative netrin-1 expression in glioma specimens of different grades. The mean integrated optical density (IOD) of netrin-1 staining was determined using Image-Pro Plus. (c) Relative netrin-1 expression in low- and high-grade gliomas. The mean IOD of netrin-1 staining was determined using Image-Pro Plus. (d) Ki-67 expression in low- and high-grade gliomas. (e) Netrin-1 expression and Ki-67 index of each glioma tumor sample were plotted for the Spearman analysis. (f) ROC analysis showed that netrin-1 expression (AUC = 0.756, p < 0.001) and Ki-67 levels (AUC = 0.901, p < 0.001) could discriminate low-grade gliomas from high-grade gliomas. One-way ANOVA and Student’s t-test were used to test for statistical significance. The data are shown as the mean ± SEM. n.s., P > 0.05.