Table 2.
Human NEK1-Interacting Proteins related to DNA damage response.
| Gene | Uniprot ID | Protein | Reference |
|---|---|---|---|
| Base excision repair | |||
| STAT1 | P42224 | Signal transducer and activator of transcription 1-alpha/beta | D |
| MRE11 | P49959 | Double-strand break repair protein MRE11 | 8 |
| UBR1 | H3BUC4 | E3 ubiquitin-protein ligase UBR1 | B |
| KI13A | Q9H1H9 | Kinesin-like protein KIF13A | A |
| Nucleotide Excision Repair | |||
| CKAP4 | Q07065 | Cytoskeleton-associated protein 4 | A |
| Fanconi Anemia | |||
| FANCA | O15360 | Fanconi anemia group A protein | D |
| RPA1 | O95602 | DNA-directed RNA polymerase I subunit RPA1 | C |
| Mismatch Repair | |||
| PM2P1 | A4D2B8 | Putative postmeiotic segregation increased 2-like protein 1 | D |
| MSH6 | P52701 | DNA mismatch repair protein Msh6 | B |
| Double Strand Break Repair | |||
| NUP153 | F6QR24 | Nuclear pore complex protein Nup153 | A |
| DMD | P11532 | Dystrophin | B |
| FLNA | P21333 | Filamin-A | B |
| VHL | P40337 | Von Hippel-Lindau protein | 79 |
| 53BP1 | Q12888 | Tumor suppressor p53-binding protein1 | 8 |
| CDC73 | Q6P1J9 | Parafibromin | A |
| HORM1 | Q86X24 | HORMA domain-containing protein1 | D |
| NSE2 | Q96MF7 | E3 SUMO-protein ligase NSE2 | C |
| BTBD2 | Q9BX70 | BTB/POZ domain-containing protein2 | C |
| XRCC5 | P13010 | X-ray repair cross-complementing protein5 | 80 |
| BAZ1A | Q9NRL2 | Bromodomain adjacent to zinc finger domain protein1 A | B |
| ATRX | P46100 | Transcriptional regulator ATRX | 8 |
| RIF1 | Q5UIP0 | Telomere-associated protein RIF1 | A |
| TLK1 | Q9UKI8 | Serine/threonine-protein kinase tousled-like 1 | 57 |
| PDS5B | Q9NTI5 | Sister chromatid cohesion protein PDS5 homologB | 81 |
| DNA Repair | |||
| CRYZL1 | A6NHJ8 | Quinone oxidoreductase-like protein1 | D |
| C21ORF2 | O43822 | Chromosome 21 open reading frame2 | 82 |
| KAT7 | O95251 | Histone acetyltransferase KAT7 | B |
| ODB2 | P11182 | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex | A |
| VDAC | P21796 | Voltage-dependent anion-selective channel protein1 | 22 |
| PRS7 | P35998 | 26 S protease regulatory subunit7 | A |
| SMBP2 | P38935 | DNA-binding protein SMUBP-2 | B |
| KC1E | P49674 | Casein kinase I isoform epsilon | B |
| PSB3 | P49720 | Proteasome subunit beta type-3 | C |
| CPT1A | P50416 | Carnitine O-palmitoyltransferase1, liver isoform | B |
| PPP2R5C | Q13362 | Serine/threonine-protein phosphatase 2 A 56 kDa regulatory subunit gamma isoform | 8 |
| ATR | Q13535 | ATR | 8 |
| ATRIP | Q8WXE1 | ATRIP | 1 6 |
| CTNNAL1 | Q9UBT7 | alfa-catulin (alfa-catenin-like) | 8 |
A- NEK1 IP-LC-MS/MS; B- NEK1 IP-LC-MS/MS + cisplatin; C- phosphoproteome in NEK1 IP-LC-MS/MS; D- phosphoproteome in NEK1 IP-LC-MS/MS + cisplatin.