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. 2017 Jul 14;7:5375. doi: 10.1038/s41598-017-05039-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Normal mode analysis of TIMP-1 structure. (a) Intrinsic dynamic of TIMP-1 along modes 7, 8 and 9. Open structures of TIMP-1 are in the upper part of the panel and closed structures are in the lower part. Arrows (blue and red) indicate the direction and the deviation (length of arrows) of each residue returning to the 3D reference structure of TIMP-1. (b) Deformation energy of each TIMP-1 residue (numbering of the mature secreted protein) along mode 7. The lowest deformation energies are coloured blue and the highest are red. (c) Visualisation of the TIMP-1 3D-structure of each amino acid deformation energy. Residues with the lowest deformation energy are thin and coloured blue and those with the highest atomic fluctuation are thick and coloured red. (d) Cα atomic fluctuation of each TIMP-1 residue (numbering of the mature secreted protein) along mode 7. The lowest atomic fluctuations are coloured blue and the highest are red. (e) Visualisation of the TIMP-1 3D-structure of each amino acid atomic fluctuation. Residues with the lowest atomic fluctuations are thin and coloured blue and those with the highest atomic fluctuations are thick and coloured red.