Table 1.

Inhibition constants (Ki) of TIMP-1 mutants against MMP-1, MMP-2, MMP-3 and MMP-9.

	Ki (nM)
	MMP-1	MMP-2	MMP-3	MMP-9
T1-WT	4.03 ± 1.57	0.09 ± 0.04	1.18 ± 0.47	4.25 ± 0.28
T1-F12A	3.82 ± 1.33	0.06 ± 0.02	0.58 ± 0.60	4.76 ± 0.57
T1-K47A	3.38 ± 2.92	0.03 ± 0.01	0.55 ± 0.19	4.40 ± 0.78

Mean values ± standard error are presented.

Data are based on three independent experiments.