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. 2017 Jul 14;7:5466. doi: 10.1038/s41598-017-05770-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Venom preconditioning reduced inflammatory markers at the right frontal peri-resection site 24 h after SBI, which was reversed with Manoalide and Zileuton. (A) Representative western blot bands showing the changes in expression of inflammation-associated markers CD45, 5-LOX, MPO and IL-1 at the peri-resection site 24 h after SBI. The expression of CD45 (B), 5-LOX (C), MPO (D) and IL-1β (E) were reduced in VPC + SBI rats compared to SPC + SBI group. Manoalide and Zileuton reversed the effects of VPC on the expression of all the inflammatory markers. *p < 0.05 vs Sham, ^∆p < 0.05 vs SPC + SBI, ^#p < 0.05 vs VPC + SBI. Data are shown as mean ± SD. n = 6/group. The full length western blot pictures are shown in Supplemental Figure S4.