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. 2017 Jul 14;7:5496. doi: 10.1038/s41598-017-05542-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CD treatment decreases susceptibility to seizures. (A,B) Injection of pentylenetetrazol (PTZ; 50 mg/ml) i.p. promptly resulted in paroxysmal events and status epilepticus in control SD fed mice. In mice receiving KD or CD treatment, the ictus (example indicated by a black bar) was triggered significantly later (SD, n = 7; KD, n = 5, p < 0.01; CD, n = 8, p < 0.001), indicating a similar protective effect of both diets. (A,C) Corroborating this finding, the frequency of interictal events (example shown by an arrow) was found to be significantly reduced in both KD and CD fed mice compared to SD controls (all p < 0.05). Calibration bars: 10 s, 500 µV. *p < 0.05, **p < 0.01, ***p < 0.001.