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. 2017 Jul 14;7:5496. doi: 10.1038/s41598-017-05542-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CD treatment reduces chronic seizure occurrence. (A) The KA mouse model of chronic epilepsy. KA (20 mM) was injected unilaterally by mean of a cannula connected to a precision pump into the intra-hippocampal region. (B) Mice under SD were left 3 weeks to develop chronic seizures and were then fed with KD or CD, controls were left on SD. (C,D) EEG detected seizures were drastically decreased in mice treated with KD (n = 8, p < 0.01) and CD (n = 13, p < 0.001) compared with SD controls (n = 10). (C,E) EEG detected seizures showed similar durations between SD, KD and CD mice. Calibration bars: 10 min, 200 µV. **p < 0.01, ***p < 0.001.