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. 2017 Jul 14;7:5496. doi: 10.1038/s41598-017-05542-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CD treatment rescues cytological and molecular correlates of chronic epilepsy. (A) Tissue obtained from the recording site of KA mice was collected for immunoblotting. (B,C) Expression of GFAP was significantly reduced in mice treated with KD and CD (n = 4 per group, all p < 0.05). (D) KA mice were prepared for histological analysis of hippocampal area CA1, CA3 and DG. This article was published in The mouse brain in stereotaxic coordinates, Paxinos, G & Franklin, K, p.98, Copyright Elsevier Academic Press, 2001. This figure is not covered by the CC BY licence. Elsevier. All rights reserved, used with permission. (E,F) Both CD and KD (CD, n = 5; KD, n = 5) fed mice showed protection against dispersion of the granule cell layer (g.c.l.) compared to SD fed mice (SD, n = 6) and mice that did not receive KA (CT, n = 3).*p < 0.05. (G–J) CD and KD fed mice were also protected against cell loss in CA1 and CA3 compared to SD animals. **p < 0.01, ***p < 0.001. (h) hilus, m.l.: molecular layer, s.l.: stratum lucidum, s.o.: stratum oriens, s.p.: stratum pyramidale, s.r.: stratum radiatum.