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. 2017 Jul 14;7:5391. doi: 10.1038/s41598-017-05217-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of lipoic acid and HFD on body weight gain and insulin resistance. Mice were fed with 9-week HFD or normal diet, with or without lipoic acid administration in drinking water (0.23% w/v) and different parameters were monitored weekly or at the end of the 9-week period. (A) Body weight changes; (B) Body weight gain; At the end of the study (week 9) the following parameters were examined: (C) Plasma triglyceride levels; (D) Fasting glucose level; (E) Glucose tolerance test; (F) Area-under the curve values of glucose tolerance test; (G) Fasting insulin levels; (H) Insulin resistance index, HOMA-IR. Data presented as mean ± SD, n ≥ 5, *p < 0.05, **p < 0.01.