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. 2017 Jul 14;7:5412. doi: 10.1038/s41598-017-05720-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell type-specific total RNA-sequencing in human post-mortem dlPFC neuronal nuclei. (a) Quantification of read counts for each transcript type that was detected using RNA-sequencing. Healthy controls are shown on the left while cocaine cases are on the right. We did not detect any statistically significant differences in abundance of transcript types across cases and controls. (b) Neuron-specific transcripts are highly expressed, including microtuble associated protein 2 (MAP2), synaptophysin (SYP), enolase 2 (ENO2), neuronal nuclear protein (NEUN, also known as RBFOX3) and postsynaptic density 95 (PSD95). The astrocyte specific protein, glial fibrillary acidic protein (GFAP) was expressed at several orders of magnitude lower levels, while microglial and oligodendrocyte specific transcripts (OLIG1/2, oligodendrocyte transcription factor 1/2; NCF1, neutrophil cytosolic factor 1; and GDF15, growth differentiation factor 15) were not detected. Y-axis is log counts Per million. Standard error of the mean is shown. Astr. – Astrocyte-specific, Oilgo. – Oligodendrocyte-specific.