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. 2017 Jul 14;7:5481. doi: 10.1038/s41598-017-05632-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Social interaction depends on the mode of re-socialization. The ratio of time taken to approach a box with a mouse to that taken to approach a box without a mouse was measured. (a) Social interaction of IS and Re-IS mice was reduced compared to that of Ctrl, while Ctrl and Re-SH mice showed a comparable score for social interaction. Re-SH mice showed higher social interaction than IS and Re-IS mice. (b) There were no differences in the distance of locomotion during social interaction test. Ctrl; n = 16, IS; n = 16, Re-IS; n = 16, Re-SH; n = 12, *p < 0.05. Error bars = SEM.