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. 2017 Jul 14;7:5459. doi: 10.1038/s41598-017-05764-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Occlusal morphology in mandibular (a,b) and maxillary (c,d) deciduous fourth premolars. (a) FOXI3+/+ variants (MAM1493, MAM1495) and (b) FOXI3 +/− variants (MAM1488, MAM2419, MAM1489). Note that the metaconid is lacking and the hypoconid is distally displaced. (c) FOXI3+/+ variant (MAM1495), (d) FOXI3 +/− variant (MAM2419). Note the size reduced metacone and the missing protoconule. All teeth are right side, except MAM1493 which is left and reflected here. Cusp abbreviation: h = hypoconid, m = metaconid, ml = metaconule, pa = paracone, pc = protocone, pl = protoconule, pt = protoconid,. Scale bar equals 5 mm.