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. 2017 Jul 14;7:5490. doi: 10.1038/s41598-017-06122-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a,b) SEM images of Fe₃O₄/ICG@PLGA/PFP NPs (a) 10000×; scale bar, 2 μm; (b) 70000×; scale bar, 200 nm); (c) TEM image of Fe₃O₄/ICG@PLGA/PFP NPs with a large amount of black Fe₃O₄ NPs embedded in the spherical shell (70000×; scale bar, 200 nm); (d) size distribution of Fe₃O₄/ICG@PLGA/PFP NPs with the average diameter of 289.6 ± 67.4 nm; (e) UV-Vis-NIR absorption spectra of Fe₃O₄/ICG@PLGA/PFP NPs, free ICG and Fe₃O₄ NPs.