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. 2017 Mar 13;36(28):3986–4000. doi: 10.1038/onc.2017.29

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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miR-377 inhibited TIC properties. (a) KYSE270 cells (left panel) and T.Tn cells (right panel) with ectopic miR-377 expression and corresponding control cells were treated with 5-FU (5 μM), DDP (20 μM) or DMSO for 72 h, and cell viability compared using MTT assay. (b) Sphere-forming ESCC cells and differentiated adherent counterparts were compared for miR-377 expression by qRT–PCR. (c) Sphere formation ability of KYSE270 and T.Tn cells transfected with 50 nm miR-377 mimic (left panel), or 0.8 μg miR-377 expressing plasmid (right panel) was compared with corresponding controls. (d) Growth curves of subcutaneous tumors formed by KYSE150-miR-377 cells (left panel) and KYSE270-miR-377 cells (right panel) compared with respective control cells expressing miR-CON (n=6/group). Bars, s.d.; *P<0.05; **P<0.01; ***P<0.001 compared with controls.